Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 2-amino-3-(4-bromobenzoyl-2,3,5,6-d4)-benzeneacetic acid, monosodium salt
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C15H7BrD4NO3 / Na
Formula Weight: 360.17079
CAS Number: 2749400-35-7
Notes: Bromfenac-d4 is intended for use as an internal standard for the quantification of bromfenac (Item No. 23763) by GC- or LC-MS. Bromfenac is an inhibitor of cyclooxygenase 2 (COX-2; IC50 = 6.6 nM) that is selective over COX-1 (IC50 = 210 nM).{39441} It inhibits prostaglandin E2 (PGE2; Item No. 14010) production in a rabbit model of LPS-induced eye inflammation. Bromfenac also decreases inflammation following cataract removal in dogs when administered as a 0.9% topical solution on a tapering schedule for 24 weeks.{39440} Formulations containing bromfenac have been used in the treatment of postoperative inflammation following cataract surgery.
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