Target: BRSK1 (pThr189)
Conjugate: ATTO 488
Product Type: Polyclonal
Immunogen: A phospho-specific peptide corresponding to residues surrounding Thr189 of human BRSK1 (AA186-192)
Swiss-Prot: Q8TDC3
Purification: Peptide Affinity Purified
Storage Buffer: 640.91mM DMSO, 136.36mM Ethanolamine, and 9.09mM Sodium Bicarbonate in 90.9% PBS
Specificity: Detects 86.753 kDa.
Cellular Localization: Cytoplasm / Nucleus
Scientific Background: BRSK1 (BR serine/threonine-protein kinase 1), also known as SAD1, is a 794 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one UBA domain and one protein kinase domain. Expressed in a variety of tissues with highest expression in testis and brain, BRSK1 uses magensium as a cofactor to catalyze the ATP-dependent phosphorylation of target proteins, including Wee 1 and Cdc25B. Via its kinase activity toward proteins that are involved in microtubule assembly, BRSK1 plays an essential role in neuronal polarization and may be involved in regulating cell cycle arrest in response to DNA damage, Two isoforms of BRSK1 exist due to alternative splicing events.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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