BTZO-1, CAS 99420-15-2

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 2-(2-pyridinyl)-4H-1,3-benzothiazin-4-one

Purity: ≥98%

Formula Markup: C13H8N2OS

Formula Weight: 240.2815

CAS Number: 99420-15-2

Notes: BTZO-1 is an antioxidant response element (ARE) activator with cardioprotective activity.{45205} It increases expression of an ARE-luciferase reporter construct in H9c2 cells in a concentration-dependent manner as well as mRNA expression of the ARE-regulated genes for the glutathione S-transferase Ya subunit (GST Ya) and heme oxygenase-1 (HO-1) in neonatal rat cardiomyocytes. BTZO-1 binds to macrophage migration inhibitory factor (MIF; Kd = 68.6 nM) and increases expression of GST Ya in H9c2 cells in a MIF-dependent manner when used at a concentration of 3 μM. It inhibits cell death induced by serum deprivation or doxorubicin (Item No. 15007) in neonatal rat cardiomyocytes in a concentration-dependent manner.

• Artikelnummer: CAY28161-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 28161-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK