C-021 (dihydrochloride) (Standard), CAS 1784252-84-1

Product Description: C-021 (dihydrochloride) (Standard) is the analytical standard of C-021 (dihydrochloride). This product is intended for research and analytical applications. C-021 dihydrochloride is a potent CC chemokine receptor-4 (CCR4) antagonist. C-021 dihydrochloride potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM, respectively. C-021 dihydrochloride effectively prevents human CCL22-derived [35S]GTPγS from binding to the receptor with an IC50 of 18 nM[1].

Formula: C27H43Cl2N5O2

References: [1]Yokoyama K, et al. Potent and orally bioavailable CCR4 antagonists: Synthesis and structure-activity relationship study of 2-aminoquinazolines. Bioorg Med Chem. 2009 Jan 1;17(1):64-73./[2]Matthew McMillin, et al. Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline. J Neuroinflammation. 2014 Jul 10;11:121.

CAS Number: 1784252-84-1

Molecular Weight: 540.57

Research Area: Inflammation/Immunology

Target: CCR;Reference Standards

• Artikelnummer: MEXHY-103364AR-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-103364AR-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK