Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (6S,9S,9aS)-hexahydro-6-[(4-hydroxyphenyl)methyl]-2,9-dimethyl-4,7-dioxo-N-(phenylmethyl)-8-(8-quinolinylmethyl)-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide
Purity: ≥98%
Formula Markup: C33H34N6O4
Formula Weight: 578.7
CAS Number: 1422253-37-9
Notes: A β-catenin/CBP inhibitor and active metabolite of PRI-724; reduces the proliferation and protein levels of cyclin D1, α-smooth muscle actin (α-Sma), and Ki-67, a marker of cell proliferation, in primary mouse HSCs at 10 µM; decreases viability in continuous culture-activated primary mouse HSCs at 10 µM; induces apoptosis in non-stem- and stem cell subpopulations of tyrosine kinase inhibitor-resistant, patient-derived, and blast crisis phase CML cells with or without co-culture of primary human bone marrow MSCs in combination with nilotinib
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