Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (3S,11aR)-N-[(2,4-difluorophenyl)methyl]-2,3,5,7,11,11a-hexahydro-6-hydroxy-3-methyl-d3-5,7-dioxo-oxazolo[3,2-a]pyrido[1,2-d]pyrazine-2,2-d2-8-carboxamide
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C19H12D5F2N3O5
Formula Weight: 410.382606
CAS Number: 2750534-77-9
Notes: Cabotegravir-d5 is intended for use as an internal standard for the quantification of cabotegravir (Item No. 27215) by GC- or LC-MS. Cabotegravir is an inhibitor of HIV-1 integrase (IC50 = 3 nM in a strand transfer assay).{45297} It inhibits HIV replication in MT-4 cells and peripheral blood mononuclear cells (PBMCs; IC50s = 1.3 and 0.2 nM, respectively). Cabotegravir (50 mg/kg) is protective against simian/human immunodeficiency virus (SHIV) infection in macaques when administered 1 week prior to viral challenge.{45298}
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