Product Description: Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels[1][2][3].
Applications: COVID-19-immunoregulation
Formula: C27H46O3
Citations: Sci Rep. 2022 Feb 22;12(1):3014./Front Pharmacol. 2020 Mar 31;11:200./Int Immunopharmacol. 2023 Jun 30;122:110558./Int J Mol Sci. 2017 Dec 19;18(12). pii: E2764./Nat Chem Biol. 2022 Aug 18./Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2117004119./Ther Adv Endocrinol. 2020 Oct 20. /Virol Sin. 2024 Aug 19:S1995-820X(24)00134-2.
References: [1]Castoldi A, et al. Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections. Eur J Pharm Biopharm. 2016 Nov 22./[2]Wei Zheng, et al. Vitamin D-induced vitamin D receptor expression induces tamoxifen sensitivity in MCF-7 stem cells via suppression of Wnt/β-catenin signaling. Biosci Rep. 2018 Dec 7;38(6):BSR20180595.
CAS Number: 63283-36-3
Molecular Weight: 418.65
Compound Purity: 99.93
Research Area: Metabolic Disease
Solubility: DMSO : 50 mg/mL (ultrasonic)
Target: Endogenous Metabolite;VD/VDR
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