Shelf life (days): 1460.0
Formulation: A lyophilisate
Formal Name: 7-(ß-D-glucopyranosyloxy)-3-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one
Purity: ≥98%
Formula Markup: C22H22O10
Formula Weight: 446.40408
CAS Number: 20633-67-4
Notes: Calycosin 7-O-β-D-glucoside is an isoflavone glycoside that has been isolated from A. mongholicus and A. membranaceus and has antioxidant, anti-inflammatory, and neuroprotective biological activities.{43143,43144,43145} It scavenges 34.5% of generated 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals compared to a vehicle control when used at a concentration of 100 μg/ml in a cell-free assay.{43143} Calycosin 7-O-β-D-glucoside (10 μg/ml) inhibits cytotoxicity, intracellular reactive oxygen species (ROS) production, and cytoskeletal defects induced by LPS in human umbilical vein endothelial cells (HUVECs).{43144} In vivo, calycosin 7-O-β-D-glucoside (26.8 mg/kg) reduces brain infarct volume in a rat model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).{43145}
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