Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 2-[[2-[(4-methoxyphenyl)amino]-4-pyrimidinyl]amino]-ethanol
Purity: ≥97%
Formula Markup: C13H16N4O2 / HCl
Formula Weight: 296.8
CAS Number: 671225-39-1
Notes: Most tissues have an endogenous pool of progenitor cells to draw from upon injury. The adult heart, however, contains a limited number of undifferentiated cells and techniques to replicate these cells from other pluripotent tissues have thus far been nonselective and inefficient. Cardiogenol C is a diaminopyrimidine compound that induces the differentiation of MHC- (myosin heavy chain) positive cardiomyocytes from embryonic stem cells with an EC50 value of 0.1 µM.{16722} About 90% of embryonic stem cells treated with 0.25 µM cardiogenol C express the cardiac muscle cell specific transcription factors GATA-4, MEF2, and Nkx2.5 and display the characteristic beating behavior of differentiated cardiomyocytes.{16722}
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