Clone Name: HMV307
Light Chain: Kappa
Product Description: This antibody was validated on 76 different Normal Tissues by IHC-P.
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Application Note: IHC-P: 1:100-1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Form: Liquid
Buffer (with preservative): PBS, 2% BSA, 0.025% ProClin 300.
Concentration: 0.22 mg/ml
Background: The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. [provided by RefSeq, Aug 2017]
Uniprot ID: P42574
Antigen Species: Human
Immunogen: Recombinant protein encompassing a sequence within the center region of human Caspase 3. The exact sequence is proprietary.
Purification: Affinity purified by Protein A.
Conjugation: Unconjugated
Full Name: caspase 3
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