Cathepsin F Inhibitor Screening Assay Kit

Products from BPS Bioscience require a minimum order value above 400€

Applications: Great for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.

Background: Cathepsin F is a lysosomal cysteine protease that belongs to the papain-like superfamily. It is secreted by macrophages and is thought to play a role in processing and loading peptides into MHC complexes. Cathepsin F is also expressed in atherosclerotic lesions, where it degrades ApoB-100, triggering LDL aggregation. It has been implicated in tumor invasion and metastasis, inducing apoptosis of gastric cancer cells, and mutations in cathepsin F have been linked to Alzheimer's disease and Type B Kuf's disease.

Description: The Cathepsin F Inhibitor Screening Assay Kit is designed to measure the protease activity of Cathepsin F for screening and profiling applications. 

Storage Stability: Up to 6 months from date of receipt, when stored as recommended

Supplied As: The Cathepsin F assay kit comes in a convenient 96-well format, with purified Cathepsin F, its fluorogenic substrate, and Cathepsin buffer for 100 enzyme reactions.

Warnings: Avoid freeze/thaw cycles.

Biosafety Level: Not applicable (BSL-1)

References: Smith, Katherine R., et al. 2013. "Cathepsin F mutations cause Type B Kufs disease, an adult-onset neuronal ceroid lipofuscinosis." Human Molec. Genetics 22(7): 1417-1423.

• Artikelnummer: BPS79971
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 79971
• Green Labware: Nein
• Verpackungseinheit: 96 rxns.
• Mengeneinheit: PAK