Target: CavBeta2
Conjugate: RPE
Product Type: Monoclonal
Clone Number: N8b/1 (Formerly sold as S8B-1)
Immunogen: Synthetic peptide amino acids 189-205 of rat CavBeta2
Swiss-Prot: Q8VGC3
Purification: Protein G Purified
Storage Buffer: 95.64mM Phosphate, 2.48mM MES and 2mM EDTA
Concentration: 1 mg/ml
Specificity: Detects ~78 kDa. No cross reactivity against Cavβ1, Cavβ3, Cavβ4.
Cellular Localization: Cell Membrane / Sarcolemma
Scientific Background: Cav Beat subunits are involved in the transport of the pore forming alpha1 subunit to the plasma membrane (1). They also shield an ER Retention signal on the alpha1 subunit, thereby guiding the pore-forming subunit to the target membrane (2, 3). They also determine the biophysical properties of the calcium channel (3).
References: 1. Dolphin A.C. (2003) J Bioenerg. Biomembr. 35: 599-620.2. Bichet D., et al. (2000) Neuron. 25: 177-190.3. Xie M., et al. (2007) J Cell Biol. 178(3): 489-502.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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