Target: Cav1.2
Conjugate: Biotin
Product Type: Monoclonal
Clone Number: S57
Immunogen: Fusion protein amino acids 1507-1733 (intracellular carboxyl terminus) of rabbit Cav1.2
Swiss-Prot: P15381
Purification: Protein G Purified
Storage Buffer: 136.36mM Ethanolamine, and 9.55mM Sodium Bicarbonate in 95.45% PBS
Concentration: 1 mg/ml
Specificity: Detects ~240kDa (varies with cell background due to glycosylation).
Cellular Localization: Membrane / Cell Membrane
Scientific Background: Cav1.2 is a cardiac L-type calcium channel, and is important for excitation and contraction of the heart (1). It may be associated with a variant of Long QT syndrome called Timothy's syndrome (2, 3) and also with Brugada syndrome. Some references also suggest it is related to bipolar disease as well (3).
References: 1. Splawski I., et al. (2004) Cell. 119 (1): 19-31.2. Krey J.F., and Dolmetsch R. (2009) Biophysical. 96 (3): 221a-222a.3. Crotti L., Celano G., Dagradi F. and Schwartz P.J. (2008) Orphanet J Rare Disease 3:18.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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