Target: Cav1.3
Conjugate: HRP
Product Type: Monoclonal
Clone Number: S48
Immunogen: Fusion protein amino acids 859-875 of rat Cav1.3
Swiss-Prot: P27732
Purification: Protein G Purified
Storage Buffer: 73.64mM Carbonate, 54.55mM Ethanolamine, 45.45mM Cyanoborohydride, 18.18mM Sodium Hydroxide and 0.23mM Citrate in dH2O
Concentration: 1 mg/ml
Specificity: Detects ~250kDa. No cross-reactivity against Cav1.2.
Cellular Localization: Membrane / Cell Membrane
Scientific Background: CaV1.3, also known as the calcium channel, voltage-dependent, L type, alpha 1D subunit (CACNA1D), is a human gene. CaV1.3 subunits are primarily expressed in neurons and neuroendocine cells. Some studies suggest however that CaV1.3 is also found in the atria, and may figure prominently in atrial arrhythmias (1). CaV1.3 also carries the primary sensory receptors of the mammalian cochlea, and are also expressed in the electromotile outer hair cells (2).
References: 1. Zhang Z., et al. (2005) Circulation 112: 1936-1944.2. Johnson S.L. and Marcotti W. (2008) The Journal of Physiology. 586: 1029-1042.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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