Target: Cav3.2
Conjugate: RPE
Product Type: Monoclonal
Clone Number: N55/10 (Formerly sold as S55-10)
Immunogen: Fusion protein amino acids 1019-1293 (II-III loop) of human Cav3.2
Swiss-Prot: O95180
Purification: Protein G Purified
Storage Buffer: 95.64mM Phosphate, 2.48mM MES and 2mM EDTA
Concentration: 1 mg/ml
Specificity: Detects ~260kDa. No cross-reactivity against Cav1.3.
Cellular Localization: Membrane
Scientific Background: CaV3.2 is a protein which in humans is encoded by the CACNA1H gene. Studies suggest certain mutations in this gene lead to childhood absence epilepsy (1, 2). Studies also suggest that the up-regulations of CaV3.2 may participate in the progression of prostate cancer toward an androgen-independent stage (3).
References: 1. Chen Y., et al. (2003) Ann. Neurol. 54(2): 239–43.2. Khosravani H., et al. (2004) J Biol Chem. 279(11): 9681-9684.3. Gackiere F., et al. (2008) J Biol Chem. 283(28): 19872.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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