CAY10452, CAS 170569-87-6

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 4-[5-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide

Purity: ≥98%

Formula Markup: C16H12F3N3O2S

Formula Weight: 367.3

CAS Number: 170569-87-6

Notes: Inhibitors of cyclooxygenase (COX) are generally grouped according to selectivity for COX-1 versus COX-2.{8244,11294} However, many COX inhibitors also show an antitumor, pro-apoptotic activity that is distinct from COX inhibition - celecoxib is an example.{9730} CAY10452 is a celecoxib analog that retains potent, selective COX-2 inhibitory activity (IC50 = 32 nM), but does not induce apoptosis in prostate cancer cell lines even at 100 µM.{12251} CAY10452 is thus a clean, selective tool for the inhibition of COX-2.

• Artikelnummer: CAY10075-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 10075-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK