Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 5-[[5-(4-fluorophenyl)-2-furanyl]methylene]-2,4-thiazolidinedione
Purity: ≥98%
Formula Markup: C14H8FNO3S
Formula Weight: 289.3
CAS Number: 328960-84-5
Notes: Phosphoinositide 3-kinase γ (PI3Kγ), expressed primarily in hematopoietic cells, plays several important roles in immunity. CAY10505 is a potent inhibitor of PI3K, selectively inhibiting the γ isoform (IC50 = 30 nM) better than the α, β, and δ isoforms (IC50 = 0.94, 20, and 20 μM, respectively).{14230} Tested against a panel of 80 other kinases, CAY10505 significantly inhibits only the unrelated casein kinase 2 (CK2, IC50 = 20 nM). It also inhibits the phosphorylation of the PI3K substrate PKB/Akt in mouse macrophages (IC50 = 228 nM).{14230} Oral administration of CAY10505 reduces neutrophil recruitment in mice to an extent that is comparable to that observed in PI3Kγ-deficient mice.{14230}
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