Product Description: CB-5339 is an oral activity potent p97 inhibitor with an IC50 [1]. CB-5339 extracted from WO2015109285A1 compound FF07.
Applications: Cancer-programmed cell death
Formula: C24H24N6O
References: [1]David Wustrow, et al. FUSED PYRIMIDINES AS INHIBITORS OF p97 COMPLEX. WO2015109285A1./[2]Roux B, et.al. Targeting acute myeloid leukemia dependency on VCP-mediated DNA repair through a selective second-generation small-molecule inhibitor. Sci Transl Med. 2021 Mar 31;13(587):eabg1168.
CAS Number: 1863952-15-1
Molecular Weight: 412.49
Compound Purity: 99.58
Research Area: Cancer
Solubility: DMSO : 100 mg/mL (ultrasonic;warming;heat to 80°C)