Description: CD104 is beta 4 integrin. It is primarily expressed in epithelial cells. Together with alpha 6 integrin, it is the cell surface receptor for laminin, where it mediates cell adhesion. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Product origin: Animal - Mus musculus (mouse), Bos taurus (bovine)
Conjugate: CF740
Concentration: 0.1 mg/mL
Storage buffer: PBS, 0.1% rBSA, 0.05% azide
Clone: UM-A9
Immunogen: Human squamous cell carcinoma (UM-SCC1)
Antibody Reactivity: CD104/integrin beta 4
References: Note: References for this clone sold by other suppliers may be listed for expected applications.
- Cancer Res (1991) 51(9):2395-402. (IP, functional studies)
- Cancer Res (1997) 57(1), 38-42. (IP, Flow, IF)
Entrez Gene ID: 3691
Expected AB Applications: Flow, surface (published for clone)/Functional studies (published for clone)/IF (published for clone)/IP (published for clone)
Z-Antibody Applications: Flow, surface (published)/Functional studies (published)/IF (published)/IP (published)
Antibody Application Notes: Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody/Immunofluorescence: 0.5-1 ug/mL/Biological blockade partially blocks laminin binding/Flow Cytometry 0.5-1 ug/million cells/0.1 mL/Optimal dilution for a specific application should be determined by user
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