Description: CD134 is a type I integral membrane protein. This receptor is expressed on activated CD4 and CD8 T cells and B cells. The CD134 binds to CD134 ligand (CD252) to provide a costimulatory signal that is independent of CD28. CD134 is involved in coordinating CD4 T cell selection, migration and cytokine differentiation in T helper (Th)1 and Th2 cells. CD134 is also involved in the stimulation of T cells, T dependent humoral response and generation of optimal CD4 T cell responses in vivo and in vitro. CD134 is expressed on activated CD4 T lymphocytes, and its ligand, CD134L, is found preferentially on activated B cells. Engagement of CD134 with its ligand, CD134L, delivers a strong costimulatory signal to effector T cells. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Product Origin: Animal - Rattus norvegicus (laboratory rat), Bos taurus (bovine)
Conjugate: CF740
Concentration: 0.1 mg/mL
Storage buffer: PBS, 0.1% rBSA, 0.05% azide
Clone: OX-86
Immunogen: Purified recombinant Mouse OX-40 antigen
Antibody Reactivity: CD134,
References: Note: References for this clone sold by other suppliers may be listed for expected applications.
- J Immunol (2000) 164:2160-2169. (functional studies)
- Exp Med (2003) 198(5): 737-746. (Flow, surface)
- Am J Respir Crit Care Med (2010) 181: 688-698. (WB)
J Leukoc Biol (2007) 81: 766-774. (IF)
Entrez Gene ID: 22163
Expected AB Applications: Flow, surface (published for clone)/Functional studies (published for clone)/IF (published for clone)/WB (published for clone)
Z-Antibody Applications: Flow, surface (published)/Functional studies (published)/IF (published)/WB (published)
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