Description: CD2 interacts through its amino-terminal domain with the extracellular domain of CD58 (also designated CD2 ligand) to mediate cell adhesion. CD2/CD58 binding can enhance antigen-specific T cell activation. CD2 is a transmembrane glycoprotein that is expressed on peripheral blood T lymphocytes, NK cells and thymocytes. CD58 is a heavily glycosylated protein with a broad tissue distribution in hematopoietic and other cells, including endothelium. Interaction between CD2 and its counter receptor LFA3 (CD58) on opposing cells optimizes immune system recognition, thereby facilitating communication between helper T lymphocytes and antigen-presenting cells, as well as between cytolytic effectors and target cells. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Product origin: Animal - Mus musculus (mouse), Bos taurus (bovine)
Conjugate: CF740
Concentration: 0.1 mg/mL
Storage buffer: PBS, 0.1% rBSA, 0.05% azide
Clone: UMCD2
Immunogen: Human Thymocytes/Sezary T cells
Antibody Reactivity: CD2/LFA-2/Lymphocyte Function Antigen 2
References: Note: References for this clone sold by other suppliers may be listed for expected applications.
- Transplant Proc (1987) 19(1):277-8. (functional studies, IP)
- Fert Stert (2008) 90,(3), P849.E5-849.E8. (IHC, frozen)
- eLife. 2018; 7: e31657. (IF, FFPE)
- Am J Transplant. 2019;20:88-100. (Flow)
Entrez Gene ID: 914
Expected AB Applications: Flow, surface (published for clone)/Functional studies (published for clone)/IHC (FFPE) (published for clone)/IF (published for clone)
Z-Antibody Applications: Flow, surface (published)/Functional studies (published)/IF (published)/IHC, FFPE (published)
Antibody Application Notes: Functional studies: Order Ab without azide; Flow cytometry: 0.5-1 ug/million cells; Immunofluorescence: 0.5-1 ug/mL; Optimal dilution for a specific application should be determined.
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