CD44v6 (Marker of Tumor Metastasis)(2F10), CF740 conjugate, 0.1mg/mL

Description: This antibody recognizes an epitope encoded by exon v6 on the variant portion of human CD44. The CD44 molecule belongs to a family of cellular adhesion molecules found on a wide range of normal and malignant cells in epithelial, mesothelial and hemopoiesis tissues. CD44 is a single gene with 20 exons, of which 10 are normally expressed to encode the basic CD44 (H-CAM) molecule. The additional 10 exons (v1 to v10) are only expressed by alternative splicing of the nuclear RNA. The expression of specific cell adhesion molecule CD44 splice variants has been reported to be associated with metastasis in certain human malignancies.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Product Origin: Animal - Mus musculus (mouse), Bos taurus (bovine)

Conjugate: CF740

Concentration: 0.1 mg/mL

Storage buffer: PBS, 0.1% rBSA, 0.05% azide

Clone: 2F10

Immunogen: Recombinant human CD44v3-10 Protein

Antibody Reactivity: CD44v6

References: Note: References for this clone sold by other suppliers may be listed for expected applications.

1. Arthritis Rheumatism (2002) 46(8): 2059-2064. (IF; IP; WB; functional studies)
2. J Inv Dermatol (2010) 130(7):1893-1903. (functional studies)
3. Cancer Sci (2015) 106: 1421-1428. (IHC, FFPE; Flow)

Entrez Gene ID: 960

Expected AB Applications: Flow, surface (published for clone)/Functional studies (published for clone)/IHC (FFPE) (published for clone)/IF (published for clone)/IP (published for clone)/WB (published for clone)

Z-Antibody Applications: Flow, surface (published)/Functional studies (published)/IF (published)/IHC, FFPE (published)/IP (published)/WB (published)

Antibody Application Notes: ELISA: For coating use Ab at 1-5 ug/mL, order Ab without BSA; Optimal dilution for a specific application should be determined./Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody

• Artikelnummer: BTMBNC741629-100
• Hersteller: Biotium
• Hersteller Artikelnummer: BNC741629-100
• Verpackungseinheit: 100 uL
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Immunofluorescence, Immunoprecipitation, Western Blotting, Flow Cytometry, Immunohistochemistry, Functional Studies
• Isotyp: IgG1 kappa
• Wirt: Mouse
• Konjugat: Conjugated, CF740