Description: Recognizes the D1 domain of an N-glycosylated glycoprotein of 120 kDa with intra-chain disulfide bonds, identified as CD50 or ICAM-3 (Leucocyte Workshop VI). CD50 is the major ligand for LFA-1 (CD11a/CD18) and may have signaling role to increase adhesion. It is expressed on thymocytes and T lymphocytes and is resistant to treatment with phosphatidylinositol (PI) phospholipase C. This MAb is excellent for staining of formalin/paraffin tissues.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Product Origin: Animal - Mus musculus (mouse), Bos taurus (bovine)
Conjugate: CF740
Concentration: 0.1 mg/mL
Storage buffer: PBS, 0.1% rBSA, 0.05% azide
Clone: CG106
Immunogen: Stimulated human leukocytes
Antibody Reactivity: CD50/ICAM3
References: Note: References for this clone sold by other suppliers may be listed for expected applications.
- J Biol Chem (1995) 270(2): 877-884. (ELISA)
- J Invest Dermatol (1995) 105, 215-219.(functional studies)
- J Cell Biol (1995) 129(4):1143-1153. (Flow, surface)
- J Immunol 1998; 161:1363-1370. (ELISA; epitope mapping)
- Am J Pathol (2001) 159(1): 285-295. (Flow, surface)
Entrez Gene ID: 3385
Expected AB Applications: ELISA (published for clone)/Flow, surface (published for clone)/Functional studies (published for clone)
Z-Antibody Applications: Flow, surface (published)/Functional studies (published)/ELISA (published)
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