Description: CD6 is a type I transmembrane glycoprotein that contains a 24-amino acid signal sequence, three extracellular scavenger receptor cysteine-rich (SRCR) domains, a membrane-spanning domain and a 44-amino acid cytoplasmic domain. The CD6 glycoprotein is tyrosine phosphorylated during TCR-mediated T cell activation. CD6 shows significant homology to CD5. CD6 is present on mature thymocytes, peripheral T cells and a subset of B cells. Antibodies to CD6 are used to deplete T cells from bone marrow transplants to prevent graft versus host disease.
Product origin: Animal - Mus musculus (mouse), Bos taurus (bovine)
Conjugate: CF740
Concentration: 0.1 mg/mL
Storage buffer: PBS, 0.1% rBSA, 0.05% azide
Clone: SPV-L14
Immunogen: CD8 cytotoxic T-cell clone
Antibody Reactivity: CD6
References: Note: References for this clone sold by other suppliers may be listed for expected applications.
- PNAS USA (1987) 84: 3861-3865. (Flow, surface; IF)
- J Inv Dermatol (1994) 102(6): 833-837. (Flow, surface)
- J Immunol (2006) 177:1152-1159. (functional studies)
- Nat Immunol (2014) 15(4): 384-392. (functional studies)
Entrez Gene ID: 923
Expected AB Applications: Flow, surface (published for clone)/Functional studies (published for clone)/IF (published for clone)
Z-Antibody Applications: Flow (verified)/Flow, surface (published)/Functional studies (published)/IF (published)/IF (verified)
Verified AB Applications: Flow (verified)/IF (verified)
Antibody Application Notes: Flow cytometry: 1-2 ug/mL/Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody/Immunofluorescence: 0.5-1 ug/mL/Optimal dilution for a specific application should be determined by user
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