CDK-IN-9, CAS 3031561-92-6

Product Description: CDK-IN-9 (compound 24) is a potent CDK inhibitor, also as a molecular glue inducing an interaction between CDK12 and DDB1, with an IC50 values of 4 nM for CDK2/E. CDK-IN-9 leads to polyubiquitination of cyclin K and its subsequent degradation. CDK-IN-9 induce apoptosis through dephosphorylation of retinoblastoma protein and RNA polymerase II[1].

Applications: Cancer-Kinase/protease

Formula: C21H24N8S

References: [1]Jorda R, et al. 3,5,7-Substituted Pyrazolo[4,3-d]Pyrimidine Inhibitors of Cyclin-Dependent Kinases and Cyclin K Degraders. J Med Chem. 2022 Jul 14;65(13):8881-8896.

CAS Number: 3031561-92-6

Molecular Weight: 420.53

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Apoptosis;CDK;DNA/RNA Synthesis;Molecular Glues

• Artikelnummer: MEXHY-150641-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-150641-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK