Product Description: CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50s of 4.7 and 1 nM.
Applications: Cancer-Kinase/protease
Formula: C24H22Cl2N6O3
References: [1]Susan LaGreca, et al. Identification of selective, orally active Tie2 kinase inhibitors and discovery of CE-245,677 and PF-371,989. Cancer Research. AACR Annual Meeting-Apr 14-18, 2007.
CAS Number: 717899-97-3
Molecular Weight: 513.38
Compound Purity: 98.14
Research Area: Cancer; Cardiovascular Disease
Solubility: DMSO : 125 mg/mL (ultrasonic)
Target: Tie;Trk Receptor