Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (9aS)-8-acetyl-9,9a-dihydro-1,3,7-trihydroxy-9a-methyl-9-oxo-4-dibenzofurancarboxamide
Purity: ≥95%
Formula Markup: C16H13NO7
Formula Weight: 331.3
CAS Number: 131436-22-1
Notes: Cercosporamide is a natural antifungal phytotoxin isolated from the Cercosporidium fungus, which infects the leaves of cassava plants.{25074} Its antifungal effect results from its selective and potent inhibition of fungal PKC-like 1 kinases (Pkc1), which are central to cell wall integrity (IC50 = 25 nM for Candida Pkc1).{25072} Cercosporamide less effectively inhibits human PKC isoforms PKCα, β, and γ (IC50s = 1.02, 0.35, and 5.8 μM, respectively), an action linked to lowering of plasma glucose in hyperglycemic mice.{25072,25075} However, it potently inhibits MAPK-interacting kinases Mnk1 and Mnk2 (IC50 = 115 and 11 nM, respectively), reducing protein translation in cancer cells.{25071,25073} Cercosporamide is orally bioavailable.{25072,25075}
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