Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: a-phenyl-N-[2,2,2-trichloro-1-[[[(4-fluoro-3-nitrophenyl)amino]thioxomethyl]amino]ethyl]-benzeneacetamide
Purity: ≥98%
Formula Markup: C23H18Cl3FN4O3S
Formula Weight: 555.8
CAS Number: 905973-89-9
Notes: CGK733 is an anticancer compound that was originally identified as an inhibitor of ataxia-telangiectasia mutated kinase (ATM) and ataxia-telangiectasia and Rad3-related kinase (ATR) in a study that has since been retracted.{64134,64135} It inhibits irradiation-induced activation of ATM in a reporter assay using HEK293 cells when used at a concentration of 10 µM but does not inhibit irradiation-induced activation of ATM or checkpoint kinase 2 (Chk2) in H460 human lung cancer cells or UV radiation-induced phosphorylation of Chk1 at serine 317 at the same concentration.{64136,64137} It also inhibits ATM activity in a bioluminescence-based reporter D54 glioblastoma mouse xenograft model when administered at a dose of 25 mg/kg.{64136} CGK733 reduces tumor growth in a CNE-2 nasopharyngeal carcinoma mouse xenograft model.{64138}
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