Formulation: A solid
Formal Name: P-(3-aminopropyl)-P-(diethoxymethyl)-phosphinic acid
Purity: ≥95%
Formula Markup: C8H20NO4P
Formula Weight: 225,2
Shelf life (days): 1460
CAS Number: 123690-79-9
Notes: The amino acid γ-aminobutyric acid (GABA) is an inhibitory neurotransmitter that acts through two families of heteromeric ligand-gated ion channels, GABAA and GABAC, and a G protein-coupled receptor, GABAB. CGP 35348 is a selective, brain-accessible GABAB receptor antagonist (IC50 = 34 µM).{30403} It blocks the action of the GABAB-selective agonist baclofen (Item No. 18600) at postsynaptic sites but not at presynaptic receptors.{30403,30400} CGP 35348 prevents baclofen-induced antinociception and muscle relaxation in mice and rats.{30402} It is commonly used to investigate the role of GABAB activation in neurological signaling.{30401,30399,30398}
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