Product Description: CGP37157 is a potent, selective inhibitor of Na+/Ca2+ exchanger, inhibiting the Na+-induced Ca2+-release from guinea-pig heart mitochondria, with an IC50 of 0.8 μM.
Applications: Cancer-programmed cell death
Formula: C15H11Cl2NOS
References: [1]Chiesi M, et al. Structural dependency of the inhibitory action of benzodiazepines and related compounds on the mitochondrial Na+-Ca2+ exchanger. Biochem Pharmacol. 1988 Nov 15;37(22):4399-403./[2]Ruiz A, et al. CGP37157, an inhibitor of the mitochondrial Na+/Ca2+ exchanger, protects neurons from excitotoxicity by blocking voltage-gated Ca2+ channels. Cell Death Dis. 2014 Apr 10;5:e1156./[3]Scherzed A, et al. Effects of salinomycin and CGP37157 on head and neck squamous cell carcinoma cell lines in vitro. Mol Med Rep. 2015 Sep;12(3):4455-61.
CAS Number: 75450-34-9
Molecular Weight: 324.22494
Compound Purity: 99.50
Research Area: Cancer; Neurological Disease
Solubility: DMSO : ≥ 125 mg/mL
Target: Na+/Ca2+ Exchanger
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