CHIR-99021 (CT99021) HCl, CAS 252917-06-9

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CAS Number: 252917-06-9

Description: Hydrochloride salt of CHIR 99021, a highly selective glycogen synthase kinase-3 (GSK-3) inhibitor that can inhibit both isoforms with IC50 of 10 nM (GSK-3α) and 6.7 nM (GSK-3β).

Purity: ≥98% by HPLC

Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

Supplied As: CHIR-99021; CT99021; 6-[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl]amino]ethylamino]pyridine-3-carbonitrile

Target: GSK-3

Biosafety Level: Not applicable (BSL-1)

References: 1. Ring et al (2003). Diabetes 52 588.
2. Pan et al (2011). Neuropsychopharmacology 36 1397.
3. Ye et al (2012). PLoS One 7 e35892.

• Artikelnummer: BPS27615-3
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 27615-3
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK