CHM-1, CAS 154554-41-3

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 6-(2-fluorophenyl)-1,3-dioxolo[4,5-g]quinolin-8(5H)-one

Purity: ≥98%

Formula Markup: C16H10FNO3

Formula Weight: 283.253943

CAS Number: 154554-41-3

Notes: CHM-1 is an inhibitor of tubulin polymerization (IC50 = 0.68 µM) with anticancer activity.{57149} It inhibits colchicine (Item No. 9000760) tubulin binding by 39% when used at a concentration of 5 µM. CHM-1 inhibits the growth of K562, NCI H226, HCT116, OVCAR-3, RXF 393L, SK-MEL-5, SF-268, and SF-295 cancer cells (mean GI50 = 130 nM). It induces apoptosis in HA22T hepatocellular carcinoma cells in a concentration-dependent manner.{57150} CHM-1 (10 mg/kg) reduces tumor volume and increases survival in an HA22T mouse xenograft model.

• Artikelnummer: CAY27647-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 27647-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK