Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 5-(3-chlorophenyl)-N-[4-(4-morpholinylmethyl)phenyl]-2-furancarboxamide
Purity: ≥95%
Formula Markup: C22H21ClN2O3
Formula Weight: 396.9
CAS Number: 638156-11-3
Notes: Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by diacylglycerol, commonly downstream of PKC signaling.{13335} The three human PKD isoforms target a variety of proteins to alter cell proliferation, survival, invasion, and protein transport.{13335,25032} CID-2011756 is an inhibitor of all three PKD isoforms (IC50s = 3.2, 0.6, and 0.7 μM for PKD1, PKD2, and PKD3, respectively).{25032} This ATP-competitive inhibitor is cell permeable, blocking the phosphorylation of PKD1 on Ser916 (an autocatalytic target) in LNCaP prostate cancer cells in response to phorbol esters (EC50 = 10 μM).{25032}
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