Ciliobrevin A, CAS 302803-72-1

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 2,4-dichloro-a-(3,4-dihydro-4-oxo-2(1H)-quinazolinylidene)-ß-oxo-benzenepropanenitrile

Purity: ≥98%

Formula Markup: C17H9Cl2N3O2

Formula Weight: 358.2

CAS Number: 302803-72-1

Notes: Ciliobrevin A is a hedgehog pathway inhibitor that blocks sonic hedgehog (Shh)-induced hedgehog pathway activation (IC50 = 7 µM).{21061} It disrupts primary cilia formation and inhibits the dynein-dependent microtubial gliding and ATPase activities of the cytoplasmic ATPases associated with various cellular activities (AAA+) family. Ciliobrevin A also inhibits mammalian target of rapamycin complex 1 (mTORC1) activity in uninfected and human cytomegalovirus (HCMV)-infected cells, suggesting that mTORC1 activation requires dynein-dependent transport for cellular activation.{34791}

• Artikelnummer: CAY22587-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 22587-25
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK