Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 5,7-dimethoxy-2H-1-benzopyran-2-one
Purity: ≥95%
Formula Markup: C11H10O4
Formula Weight: 206.1947
CAS Number: 487-06-9
Notes: Citropten is a coumarin that has been found in bergamot extracts and has diverse biological activities.{48867,48868,48869,48870} It reduces IL-8 mRNA accumulation induced by TNF-α or heat-inactivated P. aeruginosa in IB3-1 cells derived from cystic fibrosis patients.{48867} Citropten induces cell cycle arrest at the G1 phase and inhibits proliferation of A375, MCF-7, PC3, and SW620 cancer cells (IC50s = 250-325 µM).{48868} It is active against various Gram-positive and Gram-negative bacteria (MICs = 16-64 µg/ml).{48869} Citropten increases prothrombin time in isolated rat platelet-poor plasma. In vivo, citropten (10 mg/kg) prevents decreases in locomotor activity and increases in hippocampal monoamine oxidase A (MAO-A) levels in a rat model of chronic mild stress-induced depression.{48870}
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