Product Description: Cl-4AS-1, a potent steroidal androgen receptor (AR) agonist (IC50 = 12 nM), is also an inhibitor of 5α-reductase types I and II (IC50 = 6 and 10 nM, respectively)[1][2].
Applications: Cancer-programmed cell death
Formula: C26H33ClN2O2
References: [1]Schmidt A, et al. Identification of anabolic selective androgen receptor modulators with reduced activities in reproductive tissues and sebaceous glands. J Biol Chem. 2009 Dec 25;284(52):36367-36376./[2]Tolman RL, et al. 4-Methyl-3-oxo-4-aza-5alpha-androst-1-ene-17beta-N-aryl-carboxamides: an approach to combined androgen blockade [5alpha-reductase inhibition with androgen receptor binding in vitro]. J Steroid Biochem Mol Biol. 1997 Mar;60(5-6):303-9.
CAS Number: 188589-66-4
Molecular Weight: 441.01
Compound Purity: 99.64
Research Area: Cancer
Solubility: DMSO : 4.41 mg/mL (ultrasonic;warming)
Target: Androgen Receptor
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