Product Description: Clemizole hydrochloride is an H1 histamine receptor antagonist, is found to substantially inhibit HCV replication. Clemizole hydrochloride is an inhibitor of TRPC5 channel. The IC50 of Clemizole hydrochloride for RNA binding by NS4B is 24 nM, whereas its EC50 for viral replication is 8 μM.
Applications: COVID-19-anti-virus
Formula: C19H21Cl2N3
References: [1]Einav S, et al. Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis. Nat Biotechnol. 2008 Sep;26(9):1019-27/[2]Richter JM, et al. Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol Pharmacol. 2014 Nov;86(5):514-21/[3]Nishimura T, et al. Using chimeric mice with humanized livers to predict human drug metabolism and a drug-drug interaction. J Pharmacol Exp Ther. 2013 Feb;344(2):388-96.
CAS Number: 1163-36-6
Molecular Weight: 362.30
Compound Purity: 99.99
Research Area: Cancer; Inflammation/Immunology; Endocrinology
Solubility: DMSO : 33.33 mg/mL (ultrasonic)/H2O : 20 mg/mL (ultrasonic)
Target: HCV;HCV Protease;Histamine Receptor;TRP Channel
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