Product Description: Clofarabine, a nucleoside analogue for research of cancer, is a potent inhibitor of ribonucleotide reductase (IC50=65 nM) by binding to the allosteric site on the regulatory subunit[1].
Applications: Cancer-programmed cell death
Formula: C10H11ClFN5O3
References: [1]Peter L Bonate, et al. Discovery and development of clofarabine: a nucleoside analogue for treating cancer. Nat Rev Drug Discov. 2006 Oct;5(10):855-63./[2]Hai-Bo Liu, et al. [Effect of clofarabine on proliferation and Bcl-2 expression of NB4 cells]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2012 Jun;20(3):571-3./[3]Jia-Jie Luan, et al. Dosing-time contributes to chronotoxicity of clofarabine in mice via means other than pharmacokinetics. Kaohsiung J Med Sci. 2016 May;32(5):227-34.
CAS Number: 123318-82-1
Molecular Weight: 303.681
Compound Purity: 99.88
Research Area: Metabolic Disease; Cancer
Solubility: DMSO : ≥ 50 mg/mL
Target: Apoptosis;Autophagy;Nucleoside Antimetabolite/Analog
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