Product Description: Clorgyline hydrochloride is an irreversible and selective inhibitor of monoamine oxidase A (MAO-A) that is used in scientific research, structurally related to Pargyline (HY-A0091A). Clorgyline hydrochloride has little effect on the amounts of conjugated dopamine (DA) present in superfusate of slices from rat striatum. Clorgyline hydrochloride contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups[1][2][3].
Applications: Metabolism-protein/nucleotide metabolism
Formula: C13H16Cl3NO
References: [1]Murphy DL, et al. Differential trace amine alterations in individuals receiving acetylenic inhibitors of MAO-A (clorgyline) or MAO-B (selegiline and pargyline). Journal of neural transmission. Supplementum 52: 39-48./[2]Guillem K, et al. Monoamine oxidase A rather than monoamine oxidase B inhibition increases nicotine reinforcement in rats[J]. Eur J Neurosci. 2006 Dec;24(12):3532-40. /[3]Tyce GM, et al. Conjugated dopamine in superfusates of slices of rat striatum[J]. J Neurochem. 1982 Nov;39(5):1333-9.
CAS Number: 17780-75-5
Molecular Weight: 308.63
Compound Purity: 99.92
Research Area: Metabolic Disease
Solubility: DMSO : ≥ 100 mg/mL/H2O : 100 mg/mL (ultrasonic)
Target: Monoamine Oxidase
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