Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (S)-N-(1,2,3-trimethoxy-10-(methoxy-d3)-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide-2,2,2-d3
Purity: ≥99% deuterated forms (d1-d6)
Formula Markup: C22H19D6NO6
Formula Weight: 405.4734
CAS Number: 1217651-73-4
Notes: Colchicine-d6 is intended for use as an internal standard for the quantification of colchicine (Item No. 9000760) by GC- or LC-MS. Colchicine is an inhibitor of microtubule polymerization (IC50 = 3.2 μM) that binds to tubulin, which disrupts spindle formation during mitosis.{14772} It inhibits growth of MCF-7 human breast carcinoma cells with an IC50 value of 13 nM.{14772} Colchicine has anti-inflammatory activity, inhibiting neutrophil motility and activity when used at a dose of 5 μmol/kg in a mouse model of gout and preventing the deposition of uric acid.{19463,19464}
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