Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: N-[(1S)-2-[[(7S)-6,7-dihydro-5-(2-hydroxyethyl)-6-oxo-5H-pyrido[3,2-a][3]benzazepin-7-yl]amino]-1-methyl-2-oxoethyl]-4,4,4-trifluoro-butanamide
Purity: ≥95%
Formula Markup: C22H23F3N4O4
Formula Weight: 464.437789
CAS Number: 1421438-81-4
Notes: Crenigacestat is an orally bioavailable Notch inhibitor.{53344} It induces cell cycle arrest at the G0/G1 phase and decreases expression of the oncogenes MYC and CCNA1 in Caki human renal cancer cells.{35883} Crenigacestat (8 mg/kg per day) reduces tumor growth and increases survival in a 769-P mouse xenograft model.