Target Synonym: GRD;ALPS;IDDM;Cytotoxic T-lymphocyte protein;Cytotoxic T-lymphocyte-associated antigen;Cytotoxic T-Lymphocyte-Associated Protein;CELIAC;CTLA4;ALPS5;CD;CD152;CELIAC3;CTLA-4;GRD4;GSE;IDDM12;Cytotoxic T-lymphocyte protein 4;Cytotoxic T-lymphocyte-associated antigen 4;Cytotoxic T-Lymphocyte-Associated Protein 4
Background: This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
Immunogen: Recombinant Human CTLA-4 Protein
Buffer: 0.2 μm filtered solution in PBS
Dilution: WB 1:500-1:2000
Calculated MW: 25 kDa
Observed MW: 30 kDa
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