CUR61414, CAS 334998-36-6

Product Description: CUR61414 is a novel, potent and cell permeable Hedgehog signaling pathway inhibitor (IC50?=100-200 nM). CUR61414 is a small-molecule aminoproline class compound and selectively binds to smoothened (Smo) with a Ki? value of 44 nM. CUR-61414 can induce apoptosis in cancer cells without affecting neighboring non-tumor cells[1][2].

Applications: Neuroscience-Neurodegeneration

Formula: C31H42N4O5

References: [1]Williams JA, et al. Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4616-21. Epub 2003 Apr 4./[2]Frank-Kamenetsky M, et al. Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists.J Biol. 2002 Nov 6;1(2):10.

CAS Number: 334998-36-6

Molecular Weight: 550.69

Compound Purity: 99.04

Research Area: Inflammation/Immunology

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Apoptosis;Hedgehog;Smo

• Artikelnummer: MEXHY-113965-10.1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-113965-10.1
• Verpackungseinheit: 10 mM/1 ml
• Mengeneinheit: STK