Shelf life (days): 730.0
Formulation: A 10 µg/ml solution in acetonitrile
Formal Name: (6aR,11aS,11bR)-10-(acetyl-13C2)-11-hydroxy-7,7-di(methyl-13C)-2,6,6a,7,11a,11b-hexahydro-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one-1,2a,2a1,3,4,5,5a,6,6a,7,9,10,11,11a,11b,11c-13C16
Purity: ≥98%
Formula Markup: [13C]20H20N2O3
Formula Weight: 356.2
Notes: Cyclopiazonic acid-13C20 is intended for use as an internal standard for the quantification of cyclopiazonic acid (Item No. 11326) by GC- or LC-MS. Cyclopiazonic acid is a mycotoxin that has been found in Penicillium and Aspergillus and an inhibitor of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA; IC50 = 0.6 µM).{20510,20511} In vivo, cyclopiazonic acid (11-14 mg/kg) induces ptosis, hypothermia, tremor, and cachexia, as well as induces lethality (LD50 = 13 mg/kg), in rats.{61119} It induces tachycardia and sedation in rabbits when administered at a dose of 10 mg/kg.
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