Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 7-L-threonine-cyclosporin A
Purity: ≥95%
Formula Markup: C62H111N11O13
Formula Weight: 1218.61108
CAS Number: 59787-61-0
Notes: Cyclosporin C is a fungal metabolite that has been found in T. inflatum and has diverse biological activities, including antifungal, antiviral, and immunosuppressant properties.{24990,53111,53112,53113} It is active against isolates of B. cinerea, A. niger, and Alternaria, Mucor, and Penicillium species (MICs = 0.1-5 μg/ml).{53111} Cyclosporin C (15 μg/ml) inhibits vaccinia virus replication in infected BSC40 cells by 98.82%.{53112} It inhibits lymphocyte proliferation induced by the mitogens concanavalin A (ConA; Item No. 14951), phytohemagglutinin L (PHA), and pokeweed mitogen (PWM), as well as proliferation induced by alloantigen in mixed lymphocyte culture when used at a concentration of 100 ng/ml.{53113} Cyclosporin C (100 ng/ml) inhibits the local graft versus host (GVH) reaction in mice receiving splenocyte grafts.
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