Cyclothiazide, CAS 2259-96-3

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 1,1-dioxide 3-bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide

Purity: ≥95%

Formula Markup: C14H16ClN3O4S2

Formula Weight: 389.9

CAS Number: 2259-96-3

Notes: Receptors for AMPA are ionotropic glutamate receptors with critical roles in neurological development and function.{23037,21634,14541} Cyclothiazide is a benzothiadiazide that acts as a potentiator of AMPA receptors, positively modulating its response to glutamic acid (EC50 = 3.8 µM).{26686,26685,24138} It blocks the rapid agonist-induced desensitization of AMPA receptors, resulting in enhanced excitatory activity.{24138} Cyclothiazide is also a negative modulator of GABAA receptors, reversibly inhibiting both evoked and spontaneous inhibitory postsynaptic currents (IC50 = 58 µM).{26693,26687}

• Artikelnummer: CAY16335-100
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 16335-100
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK