CZC-25146, CAS 1191911-26-8

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-[2-[[5-fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-methanesulfonamide

Purity: ≥98%

Formula Markup: C22H25FN6O4S

Formula Weight: 488.5

CAS Number: 1191911-26-8

Notes: CZC-25146 is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50 = 4.76 nM for the human recombinant kinase).{32556} It also inhibits LRRK2G2019S, a mutant linked to neurotoxicity and Parkinson’s disease, with an IC50 value of 6.87 nM. CZC-25146 is selective for LRRK2 over a panel of kinases in HeLa cell lysates, Jurkat/Ramos mixed cell lysates, as well as whole mouse brain extracts (IC50s = >2 μM). It reduces LRRK2G2019S-induced cell injury in rat primary cortical neurons.

• Artikelnummer: CAY22931-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 22931-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK