Product Description: D-Arabinose (Standard) is the analytical standard of D-Arabinose. This product is intended for research and analytical applications. D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC50 is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082)[1][2][3][4].
Formula: C5H10O5
References: [1]Guo Y, et al. D-arabinose acts as antidepressant by activating the ACSS2-PPARγ/TFEB axis and CRTC1 transcription. Pharmacol Res. 2024 Apr;202:107136./[2]Sakoguchi H, et al. Growth inhibitory effect of D-arabinose against the nematode Caenorhabditis elegans: Discovery of a novel bioactive monosaccharide. Bioorg Med Chem Lett. 2016 Feb 1;26(3):726-729./[3]LeBlanc DJ, et al. Metabolism of D-arabinose: a new pathway in Escherichia coli. J Bacteriol. 1971 Apr;106(1):90-6./[4]An SJ, et al. Inhibitory effect of d-arabinose on oral bacteria biofilm formation on titanium discs. Anaerobe. 2022 Jun;75:102533.
CAS Number: 10323-20-3
Molecular Weight: 150.13
Research Area: Infection; Metabolic Disease; Neurological Disease
Target: AMPK;Bacterial;Parasite;PPAR;Reference Standards
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