Product Description: δ-Secretase inhibitor 11 (compound 11) is an orally active, potent, BBB-penetrated, non-toxic, selective and specific δ-secretase inhibitor, with an IC50 of 0.7 μM. δ-Secretase inhibitor 11 interacts with both the active site and allosteric site of δ-secretase. δ-Secretase inhibitor 11 attenuates tau and APP (amyloid precursor protein) cleavage. δ-Secretase inhibitor 11 ameliorates synaptic dysfunction and cognitive impairments in tau P301S and 5XFAD transgenic mouse models. δ-Secretase inhibitor 11 can be used for Alzheimer's disease research[1].
Applications: Neuroscience-Neurodegeneration
Formula: C10H12N4O2
References: [1]Zhang Z, et al. Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease. Nat Commun. 2017 Mar 27;8:14740.
CAS Number: 842964-18-5
Molecular Weight: 220.23
Compound Purity: 99.35
Research Area: Neurological Disease
Solubility: DMSO : 125 mg/mL (ultrasonic)
Target: Amyloid-β;Caspase
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