Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 7-hydroxy-3-(4-hydroxyphenyl-2,3,5,6-d4)-4H-1-benzopyran-4-one
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C15H6D4O4
Formula Weight: 258.3
CAS Number: 1219803-57-2
Notes: Daidzein-d4 is intended for use as an internal standard for the quantification of daidzein (Item No. 10005166) by GC- or LC-MS. Daidzein is an isoflavone phytoestrogenic compound that has been found in soybeans and other legumes.{42157} It binds to estrogen receptor β (ERβ; Ki = 2.8 µM) but not ERα at concentrations up to 1 mM.{42156} It is estrogenic in vitro, increasing gene transcription mediated by the estrogen response element (ERE) in a reporter assay in an ERβ-dependent manner (EC50 = 2.8 µM for MCF-7 cells expressing ERβ).{42157} Daidzein is an inhibitor of carbonic anhydrase (CA) that is selective for carbonic CAVII and CAXII (Kis = 4.2 and 56 nM, respectively) over CAI, II, and IV (Kis = >10,000, >10,000, and 718.7 nM, respectively).{42158} It reduces tumor growth in a PC3 prostate cancer mouse orthotopic model when administered at a dose of 50 mg/kg per day and potentiates the effects of radiation therapy.{42159}
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